Cardiovascular MRI: Quantification of 4D Flow and Myocardial Motion Velocity for Marfan Syndrome
Hsu-Hsia Peng 彭旭霞助理教授清華大學 下午 2:30–4:00 鴻經館 107 室Abstract:
Noninvasive phase-contrast magnetic resonance imaging (PC-MRI) has been used to derive several reliable hemodynamic parameters. In this talk, two topics based on the technique of PC-MRI for quantifying cardiovascular function of Marfan syndrome (MFS) patients will be presented.
The first topic will be focused on the analysis of blood flow hemodynamic quantification. In particular, the index of wall shear stress (WSS), a dragging force of flowing blood acting on vascular wall, will be discussed. The analyzed regional WSS along the aorta of MFS patients will be compared with normal controls so as to establish potential indices to predict specific sites in aorta with high risk of dissection or rupture.
With dark-blood preparation, PC-MRI can be used to evaluate the motion velocity of myocardium. Thus, the second topic of this talk will be focused on the technique of tissue phase mapping (TPM). Since myocardium is also consisted of elastic fibers, a scheme to evaluate myocardial function in MFS may also play an important role on surveillance of the progress of MFS. The three-directional wall motion velocities and time-to-peak (TTP) will be computed. The indices will be compared with age-matched normal controls to show the myocardial abnormality of MFS.