演講訊息 TALKS

Abstract： The formerly basic theory of deformable porous media was demonstrated by Biot’s linear constitutive equations, coupled with fluid flow via Darcy’s law, in 1941. During this half-century, poroelasticity theory has been applied to many scientific fields, such as biomedical engineering, and petroleum engineering. In this study, the cerebral poromechanics model that we plan to utilise originates from Zienkiewicz who proposed a version for research purpose in soil liquefaction. Two important recent landmarks in neuroscience; the glymphatic system and its functional dependence on aquaporins will be harnessed. It will be the most sophisticated and up-to-date model available, as it is very close to mimic the cerebral environment (and can naturally incorporate traditional rodent/human experimentally extracted parameters). In exploring the pathophysiology of various neurodegenerative disorders that fall within the spectrum of dementia (such as normal pressure hydrocephalus), the boundary conditions and initial conditions will be provided in order to close the governing equations. We will utilise this model to explore specific pathologies allied to hydrocephalus, via our in-house code (2D and 3D finite element based discretization of the governing equations).